Research Article Single-Round Patterned DNA Library Microarray Aptamer Lead Identification
نویسندگان
چکیده
1Human Effectiveness Directorate, 711 Human Performance Wing, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH 45433, USA 2The Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, MD 20817, USA 3Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, OH 45433, USA 4UES Inc., 4401 Dayton-Xenia Road, Dayton, Dayton, OH 45433, USA
منابع مشابه
Single-Round Patterned DNA Library Microarray Aptamer Lead Identification
A method for identifying an aptamer in a single round was developed using custom DNA microarrays containing computationally derived patterned libraries incorporating no information on the sequences of previously reported thrombin binding aptamers. The DNA library was specifically designed to increase the probability of binding by enhancing structural complexity in a sequence-space confined envi...
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